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The crystal structure of DUF198 from Nitrosomonas europaea ATCC 19718

Source organism: Nitrosomonas europaea ATCC 19718
Biochemical function: hydrolase activity
Biological process: tetrahydrofolate biosynthetic process
Cellular component: not assigned

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EC 3.5.4.16: GTP cyclohydrolase I

Reaction catalysed:
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Systematic name:
GTP 7,8-8,9-dihydrolase
Alternative Name(s):
  • Dihydroneopterin triphosphate synthase
  • GTP 8-formylhydrolase
  • GTP cyclohydrolase
  • Guanosine triphosphate 8-deformylase
  • Guanosine triphosphate cyclohydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02649
Domain description: Type I GTP cyclohydrolase folE2
Occurring in:
  1. GTP cyclohydrolase FolE2
The deposited structure of PDB entry 2r5r contains 1 copy of Pfam domain PF02649 (Type I GTP cyclohydrolase folE2) in GTP cyclohydrolase FolE2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003801
Domain description: GTP cyclohydrolase FolE2/MptA
Occurring in:
  1. GTP cyclohydrolase FolE2
IPR022838
Domain description: GTP cyclohydrolase FolE2
Occurring in:
  1. GTP cyclohydrolase FolE2

Structure domain

CATH CATH domain
3.10.270.10
Class: Alpha Beta
Architecture: Roll
Topology: Urate Oxidase
Homology: Urate Oxidase;
Occurring in:
  1. GTP cyclohydrolase FolE2
The deposited structure of PDB entry 2r5r contains 1 copy of CATH domain 3.10.270.10 (Urate Oxidase) in GTP cyclohydrolase FolE2. Showing 1 copy in chain A.

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