› 2rcq

X-ray diffraction
1.2Å resolution

Crystal structure of human apo Cellular Retinol Binding Protein II (CRBP-II)

Released:
DOI: 10.2210/pdb2rcq/pdb
PDB entry 2rcq coloured by chain, front view.
PDB entry 2rcq coloured by chain, side view.
PDB entry 2rcq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution.
Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL
Proteins 70 1626-30 (2008)
PMID: 18076076

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinol-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50120 (Residues: 2-134; Coverage: 99%)
Gene names: CRBP2, RBP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P212121
Unit cell:
a: 35.518Å b: 49.834Å c: 74.398Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.217
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Retinol-binding protein 2 (RBP2): biology and pathobiology.
Blaner et al. (2020)
5 other articles

5 mentions without citation

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
Luthra et al. (2020)
4 more