EC 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing)
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Systematic name:
DNA topoisomerase (ATP-hydrolyzing)
Alternative Name(s):
- DNA gyrase
- DNA topoisomerase II
- Type II DNA topoisomerase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 2rgr contains 1 copy of Pfam domain PF00521 (DNA gyrase/topoisomerase IV, subunit A) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_Pfam_PF00521_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of Pfam domain <span class='highlight'>PF00521 (DNA gyrase/topoisomerase IV, subunit A)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 2rgr contains 1 copy of Pfam domain PF16898 (C-terminal associated domain of TOPRIM) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_Pfam_PF16898_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of Pfam domain <span class='highlight'>PF16898 (C-terminal associated domain of TOPRIM)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 2rgr contains 1 copy of Pfam domain PF01751 (Toprim domain) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_Pfam_PF01751_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of Pfam domain <span class='highlight'>PF01751 (Toprim domain)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
InterPro annotations
IPR013757
Domain description:
DNA topoisomerase, type IIA, alpha-helical domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
3.90.199.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Topoisomerase II; domain 5
Homology:
Topoisomerase II, domain 5
Occurring in:
![The deposited structure of PDB entry 2rgr contains 1 copy of CATH domain 3.90.199.10 (Topoisomerase II; domain 5) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_CATH_3.90.199.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of CATH domain <span class='highlight'>3.90.199.10 (Topoisomerase II; domain 5)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
3.40.50.670
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Rossmann fold
Homology:
Rossmann fold
Occurring in:
![The deposited structure of PDB entry 2rgr contains 1 copy of CATH domain 3.40.50.670 (Rossmann fold) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_CATH_3.40.50.670_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of CATH domain <span class='highlight'>3.40.50.670 (Rossmann fold)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
1.10.268.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Topoisomerase; domain 3
Homology:
Topoisomerase, domain 3
Occurring in:
![The deposited structure of PDB entry 2rgr contains 1 copy of CATH domain 1.10.268.10 (Topoisomerase; domain 3) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_CATH_1.10.268.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of CATH domain <span class='highlight'>1.10.268.10 (Topoisomerase; domain 3)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
3.30.1360.40
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Gyrase A; domain 2
Homology:
Gyrase A; domain 2
Occurring in:
![The deposited structure of PDB entry 2rgr contains 1 copy of CATH domain 3.30.1360.40 (Gyrase A; domain 2) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_CATH_3.30.1360.40_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of CATH domain <span class='highlight'>3.30.1360.40 (Gyrase A; domain 2)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
![The deposited structure of PDB entry 2rgr contains 1 copy of CATH domain 3.30.1490.30 (Dna Ligase; domain 1) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_CATH_3.30.1490.30_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of CATH domain <span class='highlight'>3.30.1490.30 (Dna Ligase; domain 1)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")
SCOP annotation![The deposited structure of PDB entry 2rgr contains 1 copy of SCOP domain 56720 (Type II DNA topoisomerase) in DNA topoisomerase 2. Showing 1 copy in chain C [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/2rgr_3_A_SCOP_56720_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>2rgr</span> contains 1 copy of SCOP domain <span class='highlight'>56720 (Type II DNA topoisomerase)</span> in <span class='highlight'>DNA topoisomerase 2</span>. Showing 1 copy in chain <span class='highlight'>C [auth A]</span>.")