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Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor.

Olson LJ, Hindsgaul O, Dahms NM, Kim JJ
J Biol Chem 283 10124-34 (2008)
Related entries: 2rl7, 2rl9, 2rlb, 3cy4

Cited: 22 times
EuropePMC logo PMID: 18272523

Abstract

The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component of the lysosomal enzyme targeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and transports them to endosomal compartments. The interaction between the MPRs and its ligands is pH-dependent; the homodimeric CD-MPR binds lysosomal enzymes optimally in the pH environment of the trans Golgi network (pH approximately 6.5) and releases its cargo in acidic endosomal compartments (

Reviews - 2rl8 mentioned but not cited (1)

  1. Strategies for carbohydrate recognition by the mannose 6-phosphate receptors. Dahms NM, Olson LJ, Kim JJ. Glycobiology 18 664-678 (2008)

Articles - 2rl8 mentioned but not cited (2)

  1. Structural insights into the mechanism of pH-dependent ligand binding and release by the cation-dependent mannose 6-phosphate receptor. Olson LJ, Hindsgaul O, Dahms NM, Kim JJ. J Biol Chem 283 10124-10134 (2008)
  2. Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Olson LJ, Sun G, Bohnsack RN, Peterson FC, Dahms NM, Kim JJ. Biochemistry 49 236-246 (2010)


Reviews citing this publication (7)

  1. The repertoire of glycan determinants in the human glycome. Cummings RD. Mol Biosyst 5 1087-1104 (2009)
  2. The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management. Yadati T, Houben T, Bitorina A, Shiri-Sverdlov R. Cells 9 E1679 (2020)
  3. Carbohydrate recognition by the mannose-6-phosphate receptors. Kim JJ, Olson LJ, Dahms NM. Curr Opin Struct Biol 19 534-542 (2009)
  4. Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway. Castonguay AC, Olson LJ, Dahms NM. Biochim Biophys Acta 1810 815-826 (2011)
  5. Glucosidase II and MRH-domain containing proteins in the secretory pathway. D'Alessio C, Dahms NM. Curr Protein Pept Sci 16 31-48 (2015)
  6. Resources and Methods for Engineering "Designer" Glycan-Binding Proteins. Warkentin R, Kwan DH. Molecules 26 E380 (2021)
  7. Mechanisms regulating the sorting of soluble lysosomal proteins. Meraş İ, Maes J, Lefrancois S. Biosci Rep 42 BSR20211856 (2022)

Articles citing this publication (12)

  1. On the pH-optimum of activity and stability of proteins. Talley K, Alexov E. Proteins 78 2699-2706 (2010)
  2. Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles. Barriere H, Bagdany M, Bossard F, Okiyoneda T, Wojewodka G, Gruenert D, Radzioch D, Lukacs GL. Mol Biol Cell 20 3125-3141 (2009)
  3. A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand β-glucocerebrosidase. Zachos C, Blanz J, Saftig P, Schwake M. Traffic 13 1113-1123 (2012)
  4. Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII). Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. J Biol Chem 288 20499-20509 (2013)
  5. Optimizing pH response of affinity between protein G and IgG Fc: how electrostatic modulations affect protein-protein interactions. Watanabe H, Matsumaru H, Ooishi A, Feng Y, Odahara T, Suto K, Honda S. J Biol Chem 284 12373-12383 (2009)
  6. Receptor-mediated transport of vacuolar proteins: a critical analysis and a new model. Robinson DG, Pimpl P. Protoplasma 251 247-264 (2014)
  7. Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities. Bue CA, Barlowe C. J Biol Chem 284 24049-24060 (2009)
  8. Trafficking of Vacuolar Sorting Receptors: New Data and New Problems. Robinson DG. Plant Physiol 165 1417-1423 (2014)
  9. Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Wang R, Qi X, Schmiege P, Coutavas E, Li X. Sci Adv 6 eaaz1466 (2020)
  10. A new pH sensor localized in the Golgi apparatus of Saccharomyces cerevisiae reveals unexpected roles of Vph1p and Stv1p isoforms. Deschamps A, Colinet AS, Zimmermannova O, Sychrova H, Morsomme P. Sci Rep 10 1881 (2020)
  11. Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†. Blackler RJ, Evans DW, Smith DF, Cummings RD, Brooks CL, Braulke T, Liu X, Evans SV, Müller-Loennies S. Glycobiology 26 181-192 (2016)
  12. In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins. Alghalayini A, Hossain KR, Moghaddasi S, Turkewitz DR, D'Amario C, Wallach M, Valenzuela SM. Biomolecules 13 1394 (2023)


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