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Solution structure of Mcl-1 Complexed with Puma

Source organism: Mus musculus
Biochemical function: not assigned
Biological process: intrinsic apoptotic signaling pathway
Cellular component: mitochondrion

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00452
Domain description: Apoptosis regulator proteins, Bcl-2 family
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
The deposited structure of PDB entry 2roc contains 1 copy of Pfam domain PF00452 (Apoptosis regulator proteins, Bcl-2 family) in Induced myeloid leukemia cell differentiation protein Mcl-1 homolog. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR026298
Domain description: Bcl-2 family
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR013281
Domain description: Apoptosis regulator, Mcl-1
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR036834
Domain description: Bcl-2-like superfamily
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR031661
Domain description: Bcl-2-binding component 3
Occurring in:
  1. Bcl-2-binding component 3
IPR020726
Domain description: Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR020717
Domain description: Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR046371
Domain description: Bcl-2, Bcl-2 homology region 1-3
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR002475
Domain description: Bcl2-like
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
IPR020728
Domain description: Apoptosis regulator, Bcl-2, BH3 motif, conserved site
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Structure domain

CATH CATH domain
1.10.437.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Apoptosis Regulator Bcl-x
Homology: Blc2-like
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
The deposited structure of PDB entry 2roc contains 1 copy of CATH domain 1.10.437.10 (Apoptosis Regulator Bcl-x) in Induced myeloid leukemia cell differentiation protein Mcl-1 homolog. Showing 1 copy in chain A.
SCOP SCOP annotation
56855
Class: Membrane and cell surface proteins and peptides
Fold: Toxins' membrane translocation domains
Superfamily: Bcl-2 inhibitors of programmed cell death
Occurring in:
  1. Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
The deposited structure of PDB entry 2roc contains 1 copy of SCOP domain 56855 (Bcl-2 inhibitors of programmed cell death) in Induced myeloid leukemia cell differentiation protein Mcl-1 homolog. Showing 1 copy in chain A.

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