Function and Biology

ANIONIC SALMON TRYPSIN IN COMPLEX WITH SQUASH SEED INHIBITOR (CUCURBITA PEPO TRYPSIN INHIBITOR II)

EC 3.4.21.4: Trypsin

Reaction catalysed:
Preferential cleavage: Arg-|-, Lys-|-.
Systematic name:
-
Alternative Name(s):
  • Alpha-trypsin
  • Beta-trypsin
  • Cocoonase
  • Parenzyme
  • Parenzymol
  • Pseudotrypsin
  • Sperm receptor hydrolase
  • Tripcellim
  • Tryptar
  • Tryptase
  • Trypure

Sequence families

Pfam Protein families (Pfam)
PF00299
Domain description: Squash family serine protease inhibitor
Occurring in:
  1. Trypsin inhibitor 3
The deposited structure of PDB entry 2stb contains 1 copy of Pfam domain PF00299 (Squash family serine protease inhibitor) in Trypsin inhibitor 3. Showing 1 copy in chain B [auth I].

PF00089
Domain description: Trypsin
Occurring in:
  1. Trypsin-1
The deposited structure of PDB entry 2stb contains 1 copy of Pfam domain PF00089 (Trypsin) in Trypsin-1. Showing 1 copy in chain A [auth E].

InterPro InterPro annotations
IPR000737
Domain description: Proteinase inhibitor I7, squash
Occurring in:
  1. Trypsin inhibitor 3
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Trypsin-1
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Trypsin-1
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Trypsin-1
IPR011052
Domain description: Proteinase/amylase inhibitor domain superfamily
Occurring in:
  1. Trypsin inhibitor 3
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Trypsin-1
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Trypsin-1
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Trypsin-1

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Trypsin-1
The deposited structure of PDB entry 2stb contains 2 copies of CATH domain 2.40.10.10 (Thrombin, subunit H) in Trypsin-1. Showing 2 copies in chain A [auth E].
SCOP SCOP annotations
57028
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Plant inhibitors of proteinases and amylases
Occurring in:
  1. Trypsin inhibitor 3
The deposited structure of PDB entry 2stb contains 1 copy of SCOP domain 57028 (Plant inhibitors of proteinases and amylases) in Trypsin inhibitor 3. Showing 1 copy in chain B [auth I].
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Trypsin-1
The deposited structure of PDB entry 2stb contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Trypsin-1. Showing 1 copy in chain A [auth E].