Function and Biology

Structure of isoniazid (INH) bound to cytosolic soybean ascorbate peroxidase mutant W41A

Source organism: Glycine max
Biochemical function: metal ion binding
Biological process: cellular oxidant detoxification
Cellular component: not assigned

EC 1.11.1.11: L-ascorbate peroxidase

Reaction catalysed:
(1a) 2 L-ascorbate + H(2)O(2) + 2 H(+) = 2 monodehydroascorbate + 2 H(2)O
Systematic name:
L-ascorbate:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • Ascorbate peroxidase
  • Ascorbic acid peroxidase
  • L-ascorbic acid peroxidase
  • L-ascorbic acid-specific peroxidase

Sequence family

Pfam Protein family (Pfam)
PF00141
Domain description: Peroxidase
Occurring in:
  1. L-ascorbate peroxidase
The deposited structure of PDB entry 2vcn contains 1 copy of Pfam domain PF00141 (Peroxidase) in L-ascorbate peroxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002207
Domain description: Class I peroxidase
Occurring in:
  1. L-ascorbate peroxidase
IPR002016
Domain description: Haem peroxidase
Occurring in:
  1. L-ascorbate peroxidase
IPR019793
Domain description: Peroxidases heam-ligand binding site
Occurring in:
  1. L-ascorbate peroxidase
IPR044831
Domain description: Heme-binding peroxidase Ccp1-like
Occurring in:
  1. L-ascorbate peroxidase
IPR010255
Domain description: Haem peroxidase superfamily
Occurring in:
  1. L-ascorbate peroxidase

Structure domains

CATH CATH domains
1.10.520.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 1
Homology: Peroxidase; domain 1
Occurring in:
  1. L-ascorbate peroxidase
The deposited structure of PDB entry 2vcn contains 1 copy of CATH domain 1.10.520.10 (Peroxidase; domain 1) in L-ascorbate peroxidase. Showing 1 copy in chain A.
1.10.420.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Peroxidase; domain 2
Homology: Peroxidase, domain 2
Occurring in:
  1. L-ascorbate peroxidase
The deposited structure of PDB entry 2vcn contains 1 copy of CATH domain 1.10.420.10 (Peroxidase; domain 2) in L-ascorbate peroxidase. Showing 1 copy in chain A.