› 2vdx

X-ray diffraction
1.84Å resolution

Crystal Structure of the reactive loop Cleaved Corticosteroid Binding Globulin

Released:
DOI: 10.2210/pdb2vdx/pdb
PDB entry 2vdx coloured by chain, front view.
PDB entry 2vdx coloured by chain, side view.
PDB entry 2vdx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.
Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW
J Mol Biol 380 244-51 (2008)
PMID: 18513745

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticosteroid-binding globulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 373 amino acids
Theoretical weight: 41.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08185 (Residues: 33-405; Coverage: 97%)
Gene names: CBG, SERPINA6
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P1
Unit cell:
a: 39.941Å b: 39.74Å c: 112.113Å
α: 81.94° β: 84.06° γ: 65.39°
R-values:
R R work R free
0.194 0.192 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu et al. (2009)
11 more

8 mentions without citation

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
Chmelar et al. (2011)
7 more