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The Structural Dynamics and Energetics of an Immunodominant T-cell Receptor are Programmed by its Vbeta Domain

Source organisms:
Biochemical function: protein homodimerization activity
Biological process: negative regulation of forebrain neuron differentiation
Cellular component: HFE-transferrin receptor complex

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
The deposited structure of PDB entry 2vlk contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2vlk contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain B.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 2vlk contains 1 copy of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR BETA CHAIN
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR ALPHA CHAIN
  4. JM22 TCR BETA CHAIN
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR ALPHA CHAIN
  4. JM22 TCR BETA CHAIN
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR ALPHA CHAIN
  4. JM22 TCR BETA CHAIN
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. JM22 TCR ALPHA CHAIN
  2. JM22 TCR BETA CHAIN
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. JM22 TCR ALPHA CHAIN
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. JM22 TCR ALPHA CHAIN
  2. JM22 TCR BETA CHAIN
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR ALPHA CHAIN
  4. JM22 TCR BETA CHAIN
The deposited structure of PDB entry 2vlk contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2vlk contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain B.
The deposited structure of PDB entry 2vlk contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in JM22 TCR ALPHA CHAIN. Showing 2 copies in chain D.
The deposited structure of PDB entry 2vlk contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in JM22 TCR BETA CHAIN. Showing 2 copies in chain E.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 2vlk contains 1 copy of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
SCOP SCOP annotations
48942
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. JM22 TCR BETA CHAIN
The deposited structure of PDB entry 2vlk contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 2vlk contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Beta-2-microglobulin. Showing 1 copy in chain B.
The deposited structure of PDB entry 2vlk contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in JM22 TCR BETA CHAIN. Showing 1 copy in chain E.
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. JM22 TCR BETA CHAIN
The deposited structure of PDB entry 2vlk contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in JM22 TCR BETA CHAIN. Showing 1 copy in chain E.
54453
Class: Alpha and beta proteins (a+b)
Fold: MHC antigen-recognition domain
Superfamily: MHC antigen-recognition domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 2vlk contains 1 copy of SCOP domain 54453 (MHC antigen-recognition domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

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