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Hendra virus attachment glycoprotein in complex with human cell surface receptor ephrinB2

Source organisms:
Biochemical function: ephrin receptor binding
Biological process: ephrin receptor signaling pathway
Cellular component: membrane

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00812
Domain description: Ephrin
Occurring in:
  1. Ephrin-B2
The deposited structure of PDB entry 2vsk contains 2 copies of Pfam domain PF00812 (Ephrin) in Ephrin-B2. Showing 1 copy in chain B.

PF00423
Domain description: Haemagglutinin-neuraminidase
Occurring in:
  1. Glycoprotein G
The deposited structure of PDB entry 2vsk contains 2 copies of Pfam domain PF00423 (Haemagglutinin-neuraminidase) in Glycoprotein G. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001799
Domain description: Ephrin receptor-binding domain
Occurring in:
  1. Ephrin-B2
IPR008972
Domain description: Cupredoxin
Occurring in:
  1. Ephrin-B2
IPR019765
Domain description: Ephrin, conserved site
Occurring in:
  1. Ephrin-B2
IPR031328
Domain description: Ephrin
Occurring in:
  1. Ephrin-B2
IPR034255
Domain description: Ephrin-B ectodomain
Occurring in:
  1. Ephrin-B2
IPR000665
Domain description: Haemagglutinin/haemagglutinin-neuraminidase, paramyxovirus
Occurring in:
  1. Glycoprotein G
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Glycoprotein G

Structure domains

CATH CATH domains
2.60.40.420
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Cupredoxins - blue copper proteins
Occurring in:
  1. Ephrin-B2
The deposited structure of PDB entry 2vsk contains 2 copies of CATH domain 2.60.40.420 (Immunoglobulin-like) in Ephrin-B2. Showing 1 copy in chain B.
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Glycoprotein G
The deposited structure of PDB entry 2vsk contains 2 copies of CATH domain 2.120.10.10 (Neuraminidase) in Glycoprotein G. Showing 1 copy in chain A.

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