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Crystal structure of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12

Source organism: Escherichia coli K-12
Biochemical function: 2-keto-3-deoxy-L-rhamnonate aldolase activity
Biological process: protein hexamerization
Cellular component: cytoplasm

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EC 4.1.2.53: 2-keto-3-deoxy-L-rhamnonate aldolase

Reaction catalysed:
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde
Systematic name:
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming)
Alternative Name(s):
  • 2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming)
  • 2-dehydro-3-deoxyrhamnonate aldolase
  • 2-keto-3-deoxy acid sugar aldolase
  • KDR aldolase
  • YfaU

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03328
Domain description: HpcH/HpaI aldolase/citrate lyase family
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase
The deposited structure of PDB entry 2vws contains 3 copies of Pfam domain PF03328 (HpcH/HpaI aldolase/citrate lyase family) in 2-keto-3-deoxy-L-rhamnonate aldolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005000
Domain description: HpcH/HpaI aldolase/citrate lyase domain
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase
IPR015813
Domain description: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase
IPR040442
Domain description: Pyruvate kinase-like domain superfamily
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase
IPR023593
Domain description: 2-keto-3-deoxy-L-rhamnonate aldolase
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase

Structure domain

CATH CATH domain
3.20.20.60
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Phosphoenolpyruvate-binding domains
Occurring in:
  1. 2-keto-3-deoxy-L-rhamnonate aldolase
The deposited structure of PDB entry 2vws contains 3 copies of CATH domain 3.20.20.60 (TIM Barrel) in 2-keto-3-deoxy-L-rhamnonate aldolase. Showing 1 copy in chain A.

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