› 2vyt

X-ray diffraction
1.9Å resolution

The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine.

Released:
DOI: 10.2210/pdb2vyt/pdb
PDB entry 2vyt coloured by chain, front view.
PDB entry 2vyt coloured by chain, side view.
PDB entry 2vyt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Santiveri CM, Lechtenberg BC, Allen MD, Sathyamurthy A, Jaulent AM, Freund SM, Bycroft M
J Mol Biol 382 1107-12 (2008)
PMID: 18706910

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex comb on midleg-like protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 24.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQR0 (Residues: 23-243; Coverage: 32%)
Gene name: SCML2
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand MLZ 2 x MLZ
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 38.53Å b: 99.21Å c: 131.277Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Biochemical mechanisms of gene regulation by polycomb group protein complexes.
Müller et al. (2009)
5 more

3 mentions without citation

Combinatorial readout of dual histone modifications by paired chromatin-associated modules.
Wang et al. (2011)
2 more