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PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: proteolysis
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF05922
Domain description: Peptidase inhibitor I9
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
The deposited structure of PDB entry 2w2p contains 1 copy of Pfam domain PF05922 (Peptidase inhibitor I9) in Proprotein convertase subtilisin/kexin type 9. Showing 1 copy in chain C [auth P].

PF00082
Domain description: Subtilase family
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
The deposited structure of PDB entry 2w2p contains 1 copy of Pfam domain PF00082 (Subtilase family) in Proprotein convertase subtilisin/kexin type 9. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Low-density lipoprotein receptor
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Low-density lipoprotein receptor
IPR015500
Domain description: Peptidase S8, subtilisin-related
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
IPR000152
Domain description: EGF-type aspartate/asparagine hydroxylation site
Occurring in:
  1. Low-density lipoprotein receptor
IPR036852
Domain description: Peptidase S8/S53 domain superfamily
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
IPR010259
Domain description: Peptidase S8 propeptide/proteinase inhibitor I9
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
IPR037045
Domain description: Peptidase S8 propeptide/proteinase inhibitor I9 superfamily
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Low-density lipoprotein receptor
IPR009030
Domain description: Growth factor receptor cysteine-rich domain superfamily
Occurring in:
  1. Low-density lipoprotein receptor
IPR000209
Domain description: Peptidase S8/S53 domain
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
IPR034193
Domain description: Proteinase K-like catalytic domain
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9

Structure domains

CATH CATH domains
3.30.70.80
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Peptidase S8 propeptide/proteinase inhibitor I9
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
The deposited structure of PDB entry 2w2p contains 1 copy of CATH domain 3.30.70.80 (Alpha-Beta Plaits) in Proprotein convertase subtilisin/kexin type 9. Showing 1 copy in chain C [auth P].
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Low-density lipoprotein receptor
The deposited structure of PDB entry 2w2p contains 1 copy of CATH domain 2.10.25.10 (Laminin) in Low-density lipoprotein receptor. Showing 1 copy in chain B [auth E].
3.40.50.200
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Peptidase S8/S53 domain
Occurring in:
  1. Proprotein convertase subtilisin/kexin type 9
The deposited structure of PDB entry 2w2p contains 1 copy of CATH domain 3.40.50.200 (Rossmann fold) in Proprotein convertase subtilisin/kexin type 9. Showing 1 copy in chain A.

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