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Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

Source organism: Homo sapiens
Biochemical function: sulfatide binding
Biological process: regulation of response to endoplasmic reticulum stress
Cellular component: sarcoplasmic reticulum lumen

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF10208
Domain description: ARMET, C-terminal
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
The deposited structure of PDB entry 2w51 contains 1 copy of Pfam domain PF10208 (ARMET, C-terminal) in Mesencephalic astrocyte-derived neurotrophic factor. Showing 1 copy in chain A.

PF20145
Domain description: ARMET, N-terminal
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
The deposited structure of PDB entry 2w51 contains 1 copy of Pfam domain PF20145 (ARMET, N-terminal) in Mesencephalic astrocyte-derived neurotrophic factor. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036361
Domain description: SAP domain superfamily
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
IPR019345
Domain description: ARMET, C-terminal
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
IPR045332
Domain description: ARMET, N-terminal
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
IPR045333
Domain description: ARMET-like
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor

Structure domains

CATH CATH domains
1.10.720.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1
Homology: SAP domain
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
The deposited structure of PDB entry 2w51 contains 1 copy of CATH domain 1.10.720.30 (Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1) in Mesencephalic astrocyte-derived neurotrophic factor. Showing 1 copy in chain A.
1.10.225.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: NK-Lysin
Homology: Saposin-like
Occurring in:
  1. Mesencephalic astrocyte-derived neurotrophic factor
The deposited structure of PDB entry 2w51 contains 1 copy of CATH domain 1.10.225.10 (NK-Lysin) in Mesencephalic astrocyte-derived neurotrophic factor. Showing 1 copy in chain A.

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