› 2w9w

Solution NMR

Solution structure of jerdostatin mutant R24K from Trimeresurus jerdonii with end C-terminal residues N45G46 deleted

Released:
DOI: 10.2210/pdb2w9w/pdb
PDB entry 2w9w coloured by chain, ensemble of 40 models, front view.
PDB entry 2w9w coloured by chain, ensemble of 40 models, side view.
PDB entry 2w9w coloured by chain, ensemble of 40 models, top view.
Source organism: Protobothrops jerdonii
Primary publication:
NMR structure and dynamics of recombinant wild type and mutated jerdostatin, a selective inhibitor of integrin α1β1.
Carbajo RJ, Sanz L, Mosulén S, Pérez A, Marcinkiewicz C, Pineda-Lucena A, Calvete JJ
Proteins 79 2530-42 (2011)
PMID: 21656569

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182331 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disintegrin jerdostatin Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 4.71 KDa
Source organism: Protobothrops jerdonii
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7ZZM2 (Residues: 68-108; Coverage: 46%)
Structure domains: Disintegrin domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction.
Vasconcelos et al. (2021)
1 more

1 mention without citation

Snake Venom Metalloproteinases (SVMPs): A structure-function update.
Olaoba et al. (2020)