› 2wa0

X-ray diffraction
2.3Å resolution

Crystal structure of the human MAGEA4

Released:
DOI: 10.2210/pdb2wa0/pdb
PDB entry 2wa0 coloured by chain, front view.
PDB entry 2wa0 coloured by chain, side view.
PDB entry 2wa0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Newman JA, Cooper CD, Roos AK, Aitkenhead H, Oppermann UC, Cho HJ, Osman R, Gileadi O
OpenAccess logo PLoS One 11 e0148762 (2016)
PMID: 26910052

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoma-associated antigen 4 Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43358 (Residues: 99-317; Coverage: 69%)
Gene names: MAGE4, MAGEA4
Sequence domains: MAGE homology domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04, SLS BEAMLINE X10SA
Spacegroup: P6522
Unit cell:
a: 81.63Å b: 81.63Å c: 210.891Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.243 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases.
Lee et al. (2017)
5 more

11 mentions without citation

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Doyle et al. (2010)
10 more