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The complete structure of the archaeal 13-subunit DNA-directed RNA Polymerase

Source organism: Saccharolobus shibatae
Biochemical function: nucleotidyltransferase activity
Biological process: DNA-templated transcription
Cellular component: cytoplasm

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF04998
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
  2. DNA-directed RNA polymerase subunit Rpo1C
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase subunit Rpo1C. Showing 1 copy in chain C.

PF01194
Domain description: RNA polymerases N / 8 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo10
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01194 (RNA polymerases N / 8 kDa subunit) in DNA-directed RNA polymerase subunit Rpo10. Showing 1 copy in chain N.

PF13656
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo11
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF13656 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase subunit Rpo11. Showing 1 copy in chain L.

PF12136
Domain description: RNA polymerase Rpo13 subunit HTH domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo13
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF12136 (RNA polymerase Rpo13 subunit HTH domain) in DNA-directed RNA polymerase subunit Rpo13. Showing 1 copy in chain J.

PF01192
Domain description: RNA polymerase Rpb6
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01192 (RNA polymerase Rpb6 ) in DNA-directed RNA polymerase subunit Rpo6. Showing 1 copy in chain I.

PF01191
Domain description: RNA polymerase Rpb5, C-terminal domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01191 (RNA polymerase Rpb5, C-terminal domain) in DNA-directed RNA polymerase subunit Rpo5. Showing 1 copy in chain H.

PF16992
Domain description: DNA-directed RNA polymerase, subunit G
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo8
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF16992 (DNA-directed RNA polymerase, subunit G) in DNA-directed RNA polymerase subunit Rpo8. Showing 1 copy in chain G.

PF03874
Domain description: RNA polymerase Rpb4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF03874 (RNA polymerase Rpb4) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain F.

PF00575
Domain description: S1 RNA binding domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF00575 (S1 RNA binding domain) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain E.

PF03876
Domain description: SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF03876 (SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain E.

PF01000
Domain description: RNA polymerase Rpb3/RpoA insert domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01000 (RNA polymerase Rpb3/RpoA insert domain) in DNA-directed RNA polymerase subunit Rpo3. Showing 1 copy in chain D.

PF01193
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase subunit Rpo3. Showing 1 copy in chain D.
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase subunit Rpo11. Showing 1 copy in chain L.

PF04560
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04560 (RNA polymerase Rpb2, domain 7) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF00562
Domain description: RNA polymerase Rpb2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF00562 (RNA polymerase Rpb2, domain 6) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF04567
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04567 (RNA polymerase Rpb2, domain 5) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF04566
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04566 (RNA polymerase Rpb2, domain 4) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF04565
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04565 (RNA polymerase Rpb2, domain 3) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF04561
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04561 (RNA polymerase Rpb2, domain 2) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF04563
Domain description: RNA polymerase beta subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04563 (RNA polymerase beta subunit) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.

PF05000
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF05000 (RNA polymerase Rpb1, domain 4) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.

PF04983
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04983 (RNA polymerase Rpb1, domain 3) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.

PF00623
Domain description: RNA polymerase Rpb1, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF00623 (RNA polymerase Rpb1, domain 2) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.

PF04997
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of Pfam domain PF04997 (RNA polymerase Rpb1, domain 1) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000268
Domain description: DNA-directed RNA polymerase subunit RPABC5/Rpb10
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo10
IPR036603
Domain description: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
  2. DNA-directed RNA polymerase subunit Rpo11
IPR010924
Domain description: DNA-directed RNA polymerase subunit Rpo4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
  2. DNA-directed RNA polymerase subunit Rpo8
IPR012757
Domain description: DNA-directed RNA polymerase subunit Rpo1C
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1C
IPR012758
Domain description: DNA-directed RNA polymerase subunit Rpo1N
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR006110
Domain description: RNA polymerase, subunit omega/Rpo6/RPB6
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
IPR036161
Domain description: RPB6/omega subunit-like superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
IPR014381
Domain description: DNA-directed RNA polymerase subunit Rpo5/Rpb5
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
IPR035913
Domain description: RPB5-like RNA polymerase subunit superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
IPR031555
Domain description: DNA-directed RNA polymerase subunit Rpo8
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo8
IPR003029
Domain description: S1 domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR036898
Domain description: RNA polymerase Rpb7-like, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR036643
Domain description: DNA-directed RNA polymerase, insert domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
IPR011263
Domain description: DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
IPR015712
Domain description: DNA-directed RNA polymerase, subunit 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007081
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
  2. DNA-directed RNA polymerase subunit Rpo1C
IPR045867
Domain description: DNA-directed RNA polymerase, subunit beta-prime
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
  2. DNA-directed RNA polymerase subunit Rpo1C
IPR044893
Domain description: RNA polymerase Rpb1, clamp domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR023464
Domain description: DNA-directed RNA polymerase subunit Rpo12
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo12
IPR029040
Domain description: RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo12
IPR006591
Domain description: RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo12
IPR020789
Domain description: RNA polymerases, subunit N, zinc binding site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo10
IPR023580
Domain description: RNA polymerase subunit RPB10
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo10
IPR008193
Domain description: DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo11
IPR009025
Domain description: DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo11
IPR022905
Domain description: DNA-directed RNA polymerase subunit Rpo11-like
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo11
IPR021985
Domain description: RNA polymerase Rpo13 subunit HTH domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo13
IPR020708
Domain description: DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
IPR006111
Domain description: Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
IPR020608
Domain description: RNA polymerase, subunit H/Rpb5, conserved site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
IPR000783
Domain description: RNA polymerase, subunit H/Rpb5 C-terminal
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
IPR044876
Domain description: HRDC domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
IPR005574
Domain description: RNA polymerase subunit Rpb4/RPC9
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
IPR010997
Domain description: HRDC-like superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
IPR005576
Domain description: RNA polymerase Rpb7-like , N-terminal
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR046399
Domain description: DNA-directed RNA polymerase subunit Rpo7
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR045113
Domain description: RNA polymerase subunit Rpb7-like
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR004519
Domain description: DNA-directed RNA polymerase, subunit E/RPC8
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
IPR011262
Domain description: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
IPR001514
Domain description: DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
IPR022842
Domain description: DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
IPR007641
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007121
Domain description: RNA polymerase, beta subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR014724
Domain description: RNA polymerase Rpb2, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR037033
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007120
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007647
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR019969
Domain description: DNA-directed RNA polymerase subunit Rpo2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007646
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007645
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR037034
Domain description: RNA polymerase Rpb2, domain 2 superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007642
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007644
Domain description: RNA polymerase, beta subunit, protrusion
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
IPR007083
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR038120
Domain description: RNA polymerase Rpb1, funnel domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR007066
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR000722
Domain description: RNA polymerase, alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR006592
Domain description: RNA polymerase, N-terminal
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
IPR007080
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N

Structure domains

CATH CATH domains
3.30.1360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
  2. DNA-directed RNA polymerase subunit Rpo11
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.30.1360.10 (Gyrase A; domain 2) in DNA-directed RNA polymerase subunit Rpo3. Showing 1 copy in chain D.
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.30.1360.10 (Gyrase A; domain 2) in DNA-directed RNA polymerase subunit Rpo11. Showing 1 copy in chain L.
2.40.270.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
Homology: DNA-directed RNA polymerase, subunit 2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.40.270.10 (Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
  2. DNA-directed RNA polymerase subunit Rpo8
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain E.
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerase subunit Rpo8. Showing 1 copy in chain G.
2.40.50.150
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.40.50.150 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.
1.10.10.1950
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Arc Repressor Mutant, subunit A
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 1.10.10.1950 (Arc Repressor Mutant, subunit A) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
2.40.40.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: Barwin-like endoglucanases
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.40.40.20 (Barwin-like endoglucanases) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
2.20.28.30
Class: Mainly Beta
Architecture: Single Sheet
Topology: Rubrerythrin, domain 2
Homology: RNA polymerase ii, chain L
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo12
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.20.28.30 (Rubrerythrin, domain 2) in DNA-directed RNA polymerase subunit Rpo12. Showing 1 copy in chain P.
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo10
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in DNA-directed RNA polymerase subunit Rpo10. Showing 1 copy in chain N.
3.90.940.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Eukaryotic RPB6 RNA polymerase subunit
Homology: Eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo6
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.90.940.10 (Eukaryotic RPB6 RNA polymerase subunit) in DNA-directed RNA polymerase subunit Rpo6. Showing 1 copy in chain I.
3.90.940.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Eukaryotic RPB6 RNA polymerase subunit
Homology: RPB5-like RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo5
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.90.940.20 (Eukaryotic RPB6 RNA polymerase subunit) in DNA-directed RNA polymerase subunit Rpo5. Showing 1 copy in chain H.
1.10.150.80
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: HRDC domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 1.10.150.80 (DNA polymerase; domain 1) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain F.
6.10.140.930
Class: Special
Architecture: Helix non-globular
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo4
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 6.10.140.930 (Helix Hairpins) in DNA-directed RNA polymerase subunit Rpo4. Showing 1 copy in chain F.
3.30.1490.120
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: RNA polymerase Rpb7-like, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo7
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.30.1490.120 (Dna Ligase; domain 1) in DNA-directed RNA polymerase subunit Rpo7. Showing 1 copy in chain E.
3.30.70.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.30.70.20 (Alpha-Beta Plaits) in DNA-directed RNA polymerase subunit Rpo3. Showing 1 copy in chain D.
2.170.120.12
Class: Mainly Beta
Architecture: Beta Complex
Topology: RNA Polymerase Alpha Subunit; Chain A, domain 2
Homology: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo3
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.170.120.12 (RNA Polymerase Alpha Subunit; Chain A, domain 2) in DNA-directed RNA polymerase subunit Rpo3. Showing 1 copy in chain D.
1.10.150.390
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: DNA polymerase; domain 1
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1C
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 1.10.150.390 (DNA polymerase; domain 1) in DNA-directed RNA polymerase subunit Rpo1C. Showing 1 copy in chain C.
3.90.1800.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: DCoH-like
Homology: RNA polymerase alpha subunit dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.90.1800.10 (DCoH-like) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.
3.90.1070.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hypothetical Protein Ta0175; Chain: A, domain 2
Homology: Hypothetical Protein Ta0175; Chain: A, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.90.1070.20 (Hypothetical Protein Ta0175; Chain: A, domain 2) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.
3.90.1110.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
Homology: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo2
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.90.1110.10 (Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3) in DNA-directed RNA polymerase subunit Rpo2. Showing 1 copy in chain B.
6.20.50.80
Class: Special
Architecture: Other non-globular
Topology: N-terminal domain of TfIIb
Homology: N-terminal domain of TfIIb
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 6.20.50.80 (N-terminal domain of TfIIb) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
6.10.250.2940
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 6.10.250.2940 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
1.10.132.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Topoisomerase I; Chain A, domain 4
Homology: Topoisomerase I; Chain A, domain 4
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 1.10.132.30 (Topoisomerase I; Chain A, domain 4) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
2.60.40.2940
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 2.60.40.2940 (Immunoglobulin-like) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
4.10.320.40
Class: Few Secondary Structures
Architecture: Irregular
Topology: Dihydrolipoamide Transferase
Homology: Dihydrolipoamide Transferase
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 4.10.320.40 (Dihydrolipoamide Transferase) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.
3.30.1490.180
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: RNA polymerase ii
Occurring in:
  1. DNA-directed RNA polymerase subunit Rpo1N
The deposited structure of PDB entry 2wb1 contains 2 copies of CATH domain 3.30.1490.180 (Dna Ligase; domain 1) in DNA-directed RNA polymerase subunit Rpo1N. Showing 1 copy in chain A.

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