› 2wfu

X-ray diffraction
1.85Å resolution

Crystal structure of DILP5 variant DB

Released:
DOI: 10.2210/pdb2wfu/pdb
Model geometry
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PDB entry 2wfu coloured by chain, front view.
PDB entry 2wfu coloured by chain, side view.
PDB entry 2wfu coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation.
Sajid W, Kulahin N, Schluckebier G, Ribel U, Henderson HR, Tatar M, Hansen BF, Svendsen AM, Kiselyov VV, Nørgaard P, Wahlund PO, Brandt J, Kohanski RA, Andersen AS, De Meyts P
J Biol Chem 286 661-73 (2011)
PMID: 20974844

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181612 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like peptide 5 A chain Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.38 KDa
Source organism: Drosophila melanogaster
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q7KUD5 (Residues: 87-108; Coverage: 26%)
Gene names: CG33273, HDC09365, Ilp5
Insulin-like peptide 5 B chain Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.54 KDa
Source organism: Drosophila melanogaster
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q7KUD5 (Residues: 24-47; Coverage: 28%)
Gene names: CG33273, HDC09365, Ilp5

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P43212
Unit cell:
a: 39.789Å b: 39.789Å c: 45.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.215 0.256
Expression system: Saccharomyces cerevisiae

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Citations

14 review citations

Insulin resistance and cancer: the role of insulin and IGFs.
Djiogue et al. (2013)
13 more

2 mentions without citation

Insulin detection in diabetes mellitus: challenges and new prospects.
Vargas et al. (2023)
1 more

PDB-REDO

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