› 2wqe

X-ray diffraction
2.5Å resolution

Structure of S155R Aurora-A somatic mutant

Released:
DOI: 10.2210/pdb2wqe/pdb
PDB entry 2wqe coloured by chain, front view.
PDB entry 2wqe coloured by chain, side view.
PDB entry 2wqe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.
Bibby RA, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, Bayliss R, Linardopoulos S
J Biol Chem 284 33177-84 (2009)
PMID: 19801554

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 30.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 127-388; Coverage: 65%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 3 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 85.575Å b: 85.575Å c: 79.949Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.251
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Aurora A kinase (AURKA) in normal and pathological cell division.
Nikonova et al. (2013)
8 more

2 mentions without citation

Predicting new indications for approved drugs using a proteochemometric method.
Dakshanamurthy et al. (2012)
1 more