› 2wtv

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14965 (Residues: 122-403; Coverage: 70%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand ZZL 4 x ZZL
Ligand EDO 11 x EDO
Ligand ACT 9 x ACT
Ligand DMS 2 x DMS
2 modified residues:
Ligand TPO 8 x TPO
Ligand CME 4 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P31
Unit cell:
a: 118.707Å b: 118.707Å c: 135.89Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.164 0.211
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

The functional diversity of Aurora kinases: a comprehensive review.
Willems et al. (2018)
6 more

28 mentions without citation

Aurora A kinase (AURKA) in normal and pathological cell division.
Nikonova et al. (2013)
27 more