› 2x0c

X-ray diffraction
2Å resolution

Crystal Structure of the R7R8 domains of Talin

Released:
DOI: 10.2210/pdb2x0c/pdb
PDB entry 2x0c coloured by chain, front view.
PDB entry 2x0c coloured by chain, side view.
PDB entry 2x0c coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Central region of talin has a unique fold that binds vinculin and actin.
Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR
OpenAccess logo J Biol Chem 285 29577-87 (2010)
PMID: 20610383

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 32.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26039 (Residues: 1359-1659; Coverage: 12%)
Gene names: Tln, Tln1
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 38Å b: 66.81Å c: 185.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
10 more

11 mentions without citation

Central region of talin has a unique fold that binds vinculin and actin.
Gingras et al. (2010)
10 more