› 2x29

X-ray diffraction
2.3Å resolution

Crystal structure of human4-1BB ligand ectodomain

Released:
DOI: 10.2210/pdb2x29/pdb
PDB entry 2x29 coloured by chain, front view.
PDB entry 2x29 coloured by chain, side view.
PDB entry 2x29 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily.
Won EY, Cha K, Byun JS, Kim DU, Shin S, Ahn B, Kim YH, Rice AJ, Walz T, Kwon BS, Cho HS
J Biol Chem 285 9202-10 (2010)
PMID: 20032458

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 9 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 17.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41273 (Residues: 80-246; Coverage: 66%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P321
Unit cell:
a: 121.846Å b: 121.846Å c: 33.575Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.219 0.235
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The pharmacology of second-generation chimeric antigen receptors.
van der Stegen et al. (2015)
10 more

6 mentions without citation

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Chin et al. (2018)
5 more