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Structure of the Mycobacterium tuberculosis protein, Rv2275, demonstrates that cyclodipeptide synthetases are related to type I tRNA-Synthetases.

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: ligase activity, forming carbon-oxygen bonds
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.21: Cyclo(L-tyrosyl-L-tyrosyl) synthase

Reaction catalysed:
2 L-tyrosyl-tRNA(Tyr) = 2 tRNA(Tyr) + cyclo(L-tyrosyl-L-tyrosyl)
Systematic name:
L-tyrosyl-tRNA(Tyr):L-tyrosyl-tRNA(Tyr) tyrosyltransferase (cyclizing)
Alternative Name(s):
  • CYY synthase
  • Cyclodityrosine synthase
  • Rv2275 (gene name)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF16715
Domain description: Cyclodipeptide synthase
Occurring in:
  1. Cyclo(L-tyrosyl-L-tyrosyl) synthase
The deposited structure of PDB entry 2x9q contains 2 copies of Pfam domain PF16715 (Cyclodipeptide synthase) in Cyclo(L-tyrosyl-L-tyrosyl) synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR030903
Domain description: Cyclodipeptide synthase
Occurring in:
  1. Cyclo(L-tyrosyl-L-tyrosyl) synthase
IPR038622
Domain description: Cyclodipeptide synthase superfamily
Occurring in:
  1. Cyclo(L-tyrosyl-L-tyrosyl) synthase

Structure domain

CATH CATH domain
3.40.50.11710
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Cyclodipeptide synthase
Occurring in:
  1. Cyclo(L-tyrosyl-L-tyrosyl) synthase
The deposited structure of PDB entry 2x9q contains 2 copies of CATH domain 3.40.50.11710 (Rossmann fold) in Cyclo(L-tyrosyl-L-tyrosyl) synthase. Showing 1 copy in chain A.

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