EC 1.14.99.66: [Histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Systematic name:
[Histone H3]-N(6),N(6)-dimethyl-L-lysine(4):acceptor oxidoreductase (demethylating)
Alternative Name(s):
- Lysine-specific histone demethylase 1
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
1.20.58.1880
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology:
Methane Monooxygenase Hydroxylase; Chain G, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2xah</span> contains 1 copy of CATH domain <span class='highlight'>1.20.58.1880 (Methane Monooxygenase Hydroxylase; Chain G, domain 1)</span> in <span class='highlight'>REST corepressor 1</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2xah contains 1 copy of CATH domain 1.20.58.1880 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in REST corepressor 1. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2xah_2_B_CATH_1.20.58.1880_image-200x200.png)
1.10.287.80
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helix Hairpins
Homology:
ATP synthase, gamma subunit, helix hairpin domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2xah</span> contains 1 copy of CATH domain <span class='highlight'>1.10.287.80 (Helix Hairpins)</span> in <span class='highlight'>Lysine-specific histone demethylase 1A</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2xah contains 1 copy of CATH domain 1.10.287.80 (Helix Hairpins) in Lysine-specific histone demethylase 1A. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2xah_1_A_CATH_1.10.287.80_image-200x200.png)