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Nedd4 HECT:Ub complex

Source organisms:
Biochemical function: ubiquitin-protein transferase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.26: HECT-type E3 ubiquitin transferase

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Systematic name:
S-ubiquitinyl-[HECT-type E3-ubiquitin transferase]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming)
Alternative Name(s):
  • HECT E3 ligase
  • Ubiquitin transferase HECT-E3

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 2xbb contains 2 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain C.

PF00632
Domain description: HECT-domain (ubiquitin-transferase)
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4
The deposited structure of PDB entry 2xbb contains 2 copies of Pfam domain PF00632 (HECT-domain (ubiquitin-transferase)) in E3 ubiquitin-protein ligase NEDD4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000569
Domain description: HECT domain
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR035983
Domain description: HECT, E3 ligase catalytic domain
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4

Structure domains

CATH CATH domains
3.90.1750.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hect, E3 ligase catalytic domain fold
Homology: Hect, E3 ligase catalytic domains
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4
The deposited structure of PDB entry 2xbb contains 2 copies of CATH domain 3.90.1750.10 (Hect, E3 ligase catalytic domain fold) in E3 ubiquitin-protein ligase NEDD4. Showing 1 copy in chain A.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 2xbb contains 2 copies of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 1 copy in chain C.
3.30.2410.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Hect, E3 ligase catalytic fold
Homology: Hect, E3 ligase catalytic domain
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4
The deposited structure of PDB entry 2xbb contains 2 copies of CATH domain 3.30.2410.10 (Hect, E3 ligase catalytic fold) in E3 ubiquitin-protein ligase NEDD4. Showing 1 copy in chain A.
3.30.2160.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Hect, E3 ligase catalytic domain
Homology: Hect, E3 ligase catalytic domain
Occurring in:
  1. E3 ubiquitin-protein ligase NEDD4
The deposited structure of PDB entry 2xbb contains 2 copies of CATH domain 3.30.2160.10 (Hect, E3 ligase catalytic domain) in E3 ubiquitin-protein ligase NEDD4. Showing 1 copy in chain A.

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