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The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA

X-ray diffraction
2.1Å resolution
PDB entry 2xcs coloured by chain, front view.
PDB entry 2xcs coloured by chain, side view.
PDB entry 2xcs coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus N315
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA gyrase subunit A, DNA gyrase subunit B and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 57316.73 Å2
Buried surface area: 15703.91 Å2
Dissociation area: 3,772 Å2
Dissociation energy (ΔGdiss): 62.31 kcal/mol
Dissociation entropy (TΔSdiss): 13.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-115924

Macromolecules

DNA gyrase subunit A; DNA gyrase subunit B
Chains: B, D
Length: 692 amino acids
Theoretical weight: 78.11 KDa
Source organism: Staphylococcus aureus subsp. aureus N315
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P66937 (Residues: 410-543, 580-644; Coverage: 31%)
  • Canonical: Q99XG5 (Residues: 2-491; Coverage: 55%)
    • nullnull
Gene names: SA0005, SA0006, gyrA, gyrB
Pfam:
InterPro:
CATH: Rossmann fold
DNA gyrase subunit A in PDB entry 2xcs, assembly 1, front view.
DNA gyrase subunit A in PDB entry 2xcs, assembly 1, side view.
DNA gyrase subunit A in PDB entry 2xcs, assembly 1, top view.
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DNA chains E, F
Name: 5'-5UA*D(GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP *CP*TP*AP*CP*GP*GP*CP*T)-3'
Representative chains: E, F
Length: 20 nucleotides
Theoretical weight: 6.1 KDa
5'-5UA*D(GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP *CP*TP*AP*CP*GP*GP*CP*T)-3' in PDB entry 2xcs, assembly 1, front view.
5'-5UA*D(GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP *CP*TP*AP*CP*GP*GP*CP*T)-3' in PDB entry 2xcs, assembly 1, side view.
5'-5UA*D(GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP *CP*TP*AP*CP*GP*GP*CP*T)-3' in PDB entry 2xcs, assembly 1, top view.
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