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Crystal Structure of macrophage migration inhibitory factor homologue from Prochlorococcus marinus

Source organism: Prochlorococcus marinus str. MIT 9313
Biochemical function: phenylpyruvate tautomerase activity
Biological process: signal transduction
Cellular component: extracellular space

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EC 5.3.3.12: L-dopachrome isomerase

Reaction catalysed:
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
Systematic name:
L-dopachrome keto-enol isomerase
Alternative Name(s):
  • DCF
  • DCT
  • Dopachrome Delta(7),Delta(2)-isomerase
  • Dopachrome Delta-isomerase
  • Dopachrome conversion factor
  • Dopachrome isomerase
  • Dopachrome keto-enol isomerase
  • Dopachrome oxidoreductase
  • Dopachrome rearranging enzyme
  • Dopachrome tautomerase
  • Dopachrome-rearranging enzyme
  • L-dopachrome-methyl ester tautomerase
  • TRP
  • TRP-1
  • TRP-2
  • TRP2
  • Tryosinase-related protein-2
  • Tyrosinase-related protein 2

EC 5.3.2.1: Phenylpyruvate tautomerase

Reaction catalysed:
Keto-phenylpyruvate = enol-phenylpyruvate
Systematic name:
Phenylpyruvate keto--enol-isomerase
Alternative Name(s):
  • Phenylpyruvate keto--enol tautomerase
  • Phenylpyruvic keto--enol isomerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01187
Domain description: Macrophage migration inhibitory factor (MIF)
Occurring in:
  1. L-dopachrome isomerase
The deposited structure of PDB entry 2xcz contains 1 copy of Pfam domain PF01187 (Macrophage migration inhibitory factor (MIF)) in L-dopachrome isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001398
Domain description: Macrophage migration inhibitory factor
Occurring in:
  1. L-dopachrome isomerase
IPR014347
Domain description: Tautomerase/MIF superfamily
Occurring in:
  1. L-dopachrome isomerase

Structure domain

CATH CATH domain
3.30.429.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Macrophage Migration Inhibitory Factor
Homology: Macrophage Migration Inhibitory Factor
Occurring in:
  1. L-dopachrome isomerase
The deposited structure of PDB entry 2xcz contains 1 copy of CATH domain 3.30.429.10 (Macrophage Migration Inhibitory Factor) in L-dopachrome isomerase. Showing 1 copy in chain A.

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