› 2xn3

X-ray diffraction
2.09Å resolution

Crystal structure of thyroxine-binding globulin complexed with mefenamic acid

Released:
DOI: 10.2210/pdb2xn3/pdb
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PDB entry 2xn3 coloured by chain, front view.
PDB entry 2xn3 coloured by chain, side view.
PDB entry 2xn3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A
OpenAccess logo J Biol Chem 286 16163-73 (2011)
PMID: 21325280

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138703 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thyroxine-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 38.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 33-375; Coverage: 87%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:
Thyroxine-binding globulin Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 377-415; Coverage: 10%)
Gene names: SERPINA7, TBG

Ligands and Environments

1 bound ligand:
Ligand ID8 1 x ID8
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 172.835Å b: 41.624Å c: 56.188Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.26
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Serpin structure, function and dysfunction.
Huntington JA. (2011)
5 more

1 mention without citation

Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
Qi et al. (2011)

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