› 2xsc

X-ray diffraction
2.05Å resolution

Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli

Released:
DOI: 10.2210/pdb2xsc/pdb
PDB entry 2xsc coloured by chain, front view.
PDB entry 2xsc coloured by chain, side view.
PDB entry 2xsc coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli.
Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ
Nature 355 748-50 (1992)
PMID: 1741063

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159559 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Shiga-like toxin 1 subunit B Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 69 amino acids
Theoretical weight: 7.7 KDa
Source organism: Escherichia coli
UniProt:
  • Canonical: P69179 (Residues: 21-89; Coverage: 100%)
Gene names: sltB, stxB
Sequence domains: Shiga-like toxin beta subunit
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 59.6Å b: 102.4Å c: 56.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.142 0.192

Quick links

Citations

47 review citations

Common themes in microbial pathogenicity revisited.
Finlay et al. (1997)
46 more

3 mentions without citation

OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy.
Par et al. (2021)
2 more