› 2xvu

X-ray diffraction
2.6Å resolution

Human serum albumin complexed with dansyl-L-asparagine

Released:
DOI: 10.2210/pdb2xvu/pdb
PDB entry 2xvu coloured by chain, front view.
PDB entry 2xvu coloured by chain, side view.
PDB entry 2xvu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.
Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S
OpenAccess logo J Struct Biol 174 84-91 (2011)
PMID: 20940056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.57 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand 9DN 4 x 9DN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P1
Unit cell:
a: 54.85Å b: 55.25Å c: 119.73Å
α: 81.34° β: 90.93° γ: 64.6°
R-values:
R R work R free
0.205 0.205 0.244
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
3 more

2 mentions without citation

Binding between Saikosaponin C and Human Serum Albumin by Fluorescence Spectroscopy and Molecular Docking.
Chen et al. (2016)
1 more