› 2xvv

X-ray diffraction
2.4Å resolution

Human serum albumin complexed with dansyl-L-asparagine and myristic acid

Released:
DOI: 10.2210/pdb2xvv/pdb
PDB entry 2xvv coloured by chain, front view.
PDB entry 2xvv coloured by chain, side view.
PDB entry 2xvv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin.
Ryan AJ, Ghuman J, Zunszain PA, Chung CW, Curry S
OpenAccess logo J Struct Biol 174 84-91 (2011)
PMID: 20940056

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 585 amino acids
Theoretical weight: 66.54 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 25-609; Coverage: 99%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand MYR 6 x MYR
Ligand 9DN 2 x 9DN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: C2
Unit cell:
a: 187.84Å b: 38.89Å c: 95.52Å
α: 90° β: 106.18° γ: 90°
R-values:
R R work R free
0.206 0.206 0.25
Expression system: Komagataella pastoris

Quick links

Citations

4 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
3 more

7 mentions without citation

Unraveling the versatility of human serum albumin - A comprehensive review of its biological significance and therapeutic potential.
Ashraf et al. (2023)
6 more