EC 1.14.13.39: Nitric-oxide synthase (NADPH)
Reaction catalysed:
(1a) 2 L-arginine + 2 NADPH + 2 O(2) = 2 N(omega)-hydroxy-L-arginine + 2 NADP(+) + 2 H(2)O
Systematic name:
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Alternative Name(s):
- Endothelium-derived relaxation factor-forming enzyme
- Endothelium-derived relaxing factor synthase
- NADPH-diaphorase
- NO synthase
- NOS (gene name)
- Nitric oxide synthetase
- Nitric-oxide synthetase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
3.90.340.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Nitric Oxide Synthase; Chain A, domain 1
Homology:
Nitric Oxide Synthase; Chain A, domain 1
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2y37</span> contains 2 copies of CATH domain <span class='highlight'>3.90.340.10 (Nitric Oxide Synthase; Chain A, domain 1)</span> in <span class='highlight'>Nitric oxide synthase, inducible</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2y37 contains 2 copies of CATH domain 3.90.340.10 (Nitric Oxide Synthase; Chain A, domain 1) in Nitric oxide synthase, inducible. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2y37_1_B_CATH_3.90.340.10_image-200x200.png)
3.90.440.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Nitric Oxide Synthase;Heme Domain; Chain A, domain 2
Homology:
Nitric Oxide Synthase;Heme Domain;Chain A domain 2
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2y37</span> contains 2 copies of CATH domain <span class='highlight'>3.90.440.10 (Nitric Oxide Synthase;Heme Domain; Chain A, domain 2)</span> in <span class='highlight'>Nitric oxide synthase, inducible</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2y37 contains 2 copies of CATH domain 3.90.440.10 (Nitric Oxide Synthase;Heme Domain; Chain A, domain 2) in Nitric oxide synthase, inducible. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2y37_1_B_CATH_3.90.440.10_image-200x200.png)