› 2yby

X-ray diffraction
1.58Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.39 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P06909 (Residues: 321-444; Coverage: 10%)
Gene names: Cfh, Hf1
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 29.62Å b: 34.611Å c: 107.357Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.217
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Structural vaccinology starts to deliver.
Dormitzer et al. (2012)
11 more

1 mention without citation

Structural evolution of an immune evasion determinant shapes pathogen host tropism.
Marcinkiewicz et al. (2023)