› 2ygw

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
Malonyl-CoA = acetyl-CoA + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-523109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malonyl-CoA decarboxylase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 460 amino acids
Theoretical weight: 51.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95822 (Residues: 40-490; Coverage: 92%)
Gene name: MLYCD
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand UNX 2 x UNX
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 95.627Å b: 175.342Å c: 151.756Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.255
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 citation in other articles

Genomic Sequencing for Newborn Screening: Results of the NC NEXUS Project.
Roman et al. (2020)
10 more

5 mentions without citation

From structural biology to designing therapy for inborn errors of metabolism.
Yue WW. (2016)
4 more