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Structure of the human LINE-1 ORF1p trimer

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF17490
Domain description: L1 transposable element dsRBD-like domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of Pfam domain PF17490 (L1 transposable element dsRBD-like domain) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.

PF02994
Domain description: L1 transposable element RBD-like domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of Pfam domain PF02994 (L1 transposable element RBD-like domain) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.

PF17489
Domain description: L1 transposable element trimerization domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of Pfam domain PF17489 (L1 transposable element trimerization domain) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR035300
Domain description: L1 transposable element, dsRBD-like domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
IPR042566
Domain description: L1 transposable element, C-terminal domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
IPR043636
Domain description: L1 transposable element, RRM domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
IPR035301
Domain description: L1 transposable element, trimerization domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
IPR004244
Domain description: Transposase, L1
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein

Structure domains

CATH CATH domains
3.30.250.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Rec A Protein; domain 2
Homology: L1 transposable element, C-terminal domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of CATH domain 3.30.250.20 (Rec A Protein; domain 2) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.
3.30.70.1820
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: L1 transposable element, RRM domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of CATH domain 3.30.70.1820 (Alpha-Beta Plaits) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.
1.20.5.390
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: L1 transposable element, trimerization domain
Occurring in:
  1. LINE-1 retrotransposable element ORF1 protein
The deposited structure of PDB entry 2ykq contains 3 copies of CATH domain 1.20.5.390 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in LINE-1 retrotransposable element ORF1 protein. Showing 1 copy in chain A.

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