EC 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase
Reaction catalysed:
4-hydroxyphenylacetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(2)O
Systematic name:
4-hydroxyphenylacetate,FAD:oxygen oxidoreductase (3-hydroxylating)
Alternative Name(s):
- 4 HPA 3-hydroxylase
- 4-hydroxyphenylacetic acid-3-hydroxylase
- HpaB
- p-hydroxyphenylacetate 3-hydroxylase
- p-hydroxyphenylacetate 3-hydroxylase (FAD)
- p-hydroxyphenylacetate hydroxylase
- p-hydroxyphenylacetate hydroxylase (FAD)
GO terms
Biochemical function:
- 4-hydroxyphenylacetate 3-monooxygenase activity
- flavin adenine dinucleotide binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxidoreductase activity, acting on the CH-CH group of donors
- monooxygenase activity
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
IPR046373
Domain description:
Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Occurring in:
Occurring in:
Structure domains
CATH domains
1.20.140.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homology:
Butyryl-CoA Dehydrogenase, subunit A, domain 3
Occurring in:
2.40.110.10
Class:
Mainly Beta
Architecture:
Beta Barrel
Topology:
Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homology:
Butyryl-CoA Dehydrogenase, subunit A, domain 2
Occurring in:
