› 2zk0

X-ray diffraction
2.36Å resolution

Human peroxisome proliferator-activated receptor gamma ligand binding domain

Released:
DOI: 10.2210/pdb2zk0/pdb
Model geometry
Fit model/data
PDB entry 2zk0 coloured by chain, front view.
PDB entry 2zk0 coloured by chain, side view.
PDB entry 2zk0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids.
Waku T, Shiraki T, Oyama T, Fujimoto Y, Maebara K, Kamiya N, Jingami H, Morikawa K
J Mol Biol 385 188-99 (2009)
PMID: 18977231

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 223-504; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 92.755Å b: 61.665Å c: 118.603Å
α: 90° β: 102.69° γ: 90°
R-values:
R R work R free
0.249 0.249 0.313
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Wang et al. (2014)
26 more

1 mention without citation

Virtual Screening as a Technique for PPAR Modulator Discovery.
Lewis et al. (2010)