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Crystal structure of APO form of rat catechol-O-methyltransferase

X-ray diffraction
2.2Å resolution
PDB entry 2zlb coloured by chain, front view.
PDB entry 2zlb coloured by chain, side view.
PDB entry 2zlb coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Catechol O-methyltransferase
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Multimeric state: monomeric
Accessible surface area: 9729.8 Å2
Buried surface area: 227.51 Å2
Dissociation area: 113.76 Å2
Dissociation energy (ΔGdiss): 21.49 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149780

Macromolecules

Catechol O-methyltransferase
Chain: A
Length: 223 amino acids
Theoretical weight: 24.92 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22734 (Residues: 44-264; Coverage: 84%)
  • Best match: P22734-2 (Residues: 1-221)
Gene name: Comt
Pfam: O-methyltransferase
InterPro:
CATH: Vaccinia Virus protein VP39
SCOP: COMT-like
Catechol O-methyltransferase in PDB entry 2zlb, assembly 1, front view.
Catechol O-methyltransferase in PDB entry 2zlb, assembly 1, side view.
Catechol O-methyltransferase in PDB entry 2zlb, assembly 1, top view.
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