› 2zt8

X-ray diffraction
3.35Å resolution

Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog

Released:
DOI: 10.2210/pdb2zt8/pdb
PDB entry 2zt8 coloured by chain, front view.
PDB entry 2zt8 coloured by chain, side view.
PDB entry 2zt8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guo RT, Yang XL, Schimmel P

Function and Biology Details

Reaction catalysed: 
ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine--tRNA ligase Chain: A
Molecule details ›
Chain: A
Length: 693 amino acids
Theoretical weight: 78.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41250 (Residues: 55-739; Coverage: 93%)
Gene names: GARS, GARS1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand DRV 1 x DRV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2221
Unit cell:
a: 119.6Å b: 138.258Å c: 132.703Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.246
Expression system: Escherichia coli

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