› 385d

X-ray diffraction
1.6Å resolution

FORMATION OF A NEW COMPOUND IN THE CRYSTAL STRUCTURE OF CYANOMORPHOLINODOXORUBICIN COMPLEXED WITH D(CGATCG)

Released:
DOI: 10.2210/pdb385d/pdb
PDB entry 385d coloured by chain, front view.
PDB entry 385d coloured by chain, side view.
PDB entry 385d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Degradation of the morpholino ring in the crystal structure of cyanomorpholinodoxorubicin complexed with d(CGATCG).
Ettorre A, Cirilli M, Ughetto G
Eur J Biochem 258 350-4 (1998)
PMID: 9874199

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116043 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NOD 1 x NOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 28.13Å b: 28.13Å c: 53.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 not available 0.217
Expression system: Not provided

Quick links

Citations

1 review citation

Anthracycline drug targeting: cytoplasmic versus nuclear--a fork in the road.
Lothstein et al. (2001)
2 other articles

21 mentions without citation

Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance.
Nguyen et al. (2018)
20 more