› 3a98

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-571596 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dedicator of cytokinesis protein 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 184 amino acids
Theoretical weight: 21.4 KDa
Source organism: Homo sapiens
Expression system: Cell free protein synthesis
UniProt:
  • Canonical: Q92608 (Residues: 1-177; Coverage: 10%)
Gene names: DOCK2, KIAA0209
Sequence domains:
Structure domains:
Engulfment and cell motility protein 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 203 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Cell free protein synthesis
UniProt:
  • Canonical: Q92556 (Residues: 532-727; Coverage: 27%)
Gene names: ELMO1, KIAA0281
Sequence domains: Pleckstrin homology domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 63.837Å b: 104.028Å c: 124.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.268
Expression system: Cell free protein synthesis

Quick links

Citations

15 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
14 more

10 mentions without citation

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors.
Thompson et al. (2021)
9 more