› 3b3l

X-ray diffraction
2.9Å resolution

Crystal structures of alternatively-spliced isoforms of human ketohexokinase

Released:
DOI: 10.2210/pdb3b3l/pdb
PDB entry 3b3l coloured by chain, front view.
PDB entry 3b3l coloured by chain, side view.
PDB entry 3b3l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Trinh CH, Asipu A, Bonthron DT, Phillips SEV

Function and Biology Details

Reaction catalysed: 
ATP + D-fructose = ADP + D-fructose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-546466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketohexokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 298 amino acids
Theoretical weight: 32.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50053 (Residues: 1-298; Coverage: 100%)
Gene name: KHK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P212121
Unit cell:
a: 90.555Å b: 140.704Å c: 179.262Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.236 0.281
Expression system: Escherichia coli

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