› 3c0h

X-ray diffraction
2.3Å resolution

CASK CaM-Kinase Domain- AMPPNP complex, P1 form

Released:
DOI: 10.2210/pdb3c0h/pdb
PDB entry 3c0h coloured by chain, front view.
PDB entry 3c0h coloured by chain, side view.
PDB entry 3c0h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CASK Functions as a Mg2+-independent neurexin kinase.
Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC
Cell 133 328-39 (2008)
PMID: 18423203

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-518249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peripheral plasma membrane protein CASK Chains: A, B
Molecule details ›
Chains: A, B
Length: 351 amino acids
Theoretical weight: 39.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14936 (Residues: 1-337; Coverage: 36%)
Gene names: CASK, LIN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AMP 2 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P1
Unit cell:
a: 55.387Å b: 59.675Å c: 61.086Å
α: 90° β: 105.57° γ: 105.63°
R-values:
R R work R free
0.191 0.188 0.239
Expression system: Escherichia coli BL21

Quick links

Citations

52 review citations

Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC. (2008)
51 more

5 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
4 more