› 3cqe

X-ray diffraction
2.5Å resolution

Wee1 kinase complex with inhibitor PD074291

Released:
DOI: 10.2210/pdb3cqe/pdb
PDB entry 3cqe coloured by chain, front view.
PDB entry 3cqe coloured by chain, side view.
PDB entry 3cqe coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Squire CJ, Baker EN

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-542143 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wee1-like protein kinase Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30291 (Residues: 291-575; Coverage: 44%)
Gene name: WEE1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand P91 1 x P91
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P41212
Unit cell:
a: 69.304Å b: 69.304Å c: 157.601Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.268
Expression system: Spodoptera frugiperda

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