› 3dsh

X-ray diffraction
2Å resolution

Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain

Released:
DOI: 10.2210/pdb3dsh/pdb
PDB entry 3dsh coloured by chain, front view.
PDB entry 3dsh coloured by chain, side view.
PDB entry 3dsh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Chen W, Lam SS, Srinath H, Jiang Z, Correia JJ, Schiffer CA, Fitzgerald KA, Lin K, Royer WE
Nat Struct Mol Biol 15 1213-20 (2008)
PMID: 18836453

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171764 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon regulatory factor 5 Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13568 (Residues: 232-477; Coverage: 49%)
Gene name: IRF5
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A, RIGAKU RUH3R
Spacegroup: P3121
Unit cell:
a: 66.162Å b: 66.162Å c: 156.254Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.242
Expression system: Escherichia coli

Quick links

Citations

23 review citations

IRF7: activation, regulation, modification and function.
Ning et al. (2011)
22 more

15 mentions without citation

Interferon Regulatory Factor 9 Structure and Regulation.
Paul et al. (2018)
14 more