› 3ejo

X-ray diffraction
2.3Å resolution

Coproporphyrinogen III oxidase from Leishmania donovani

Released:
DOI: 10.2210/pdb3ejo/pdb
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PDB entry 3ejo coloured by chain, front view.
PDB entry 3ejo coloured by chain, side view.
PDB entry 3ejo coloured by chain, top view.
Source organism: Leishmania donovani
Entry authors: Larson ET, Merritt EA, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)

Function and Biology Details

Reaction catalysed: 
Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
coproporphyrinogen oxidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.71 KDa
Source organism: Leishmania donovani
Expression system: Escherichia coli
UniProt:
  • Canonical: D0VX00 (Residues: 1-302; Coverage: 100%)
Sequence domains: Coproporphyrinogen III oxidase
Structure domains: Coproporphyrinogen III oxidase, aerobic

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 53.067Å b: 53.991Å c: 65.565Å
α: 86.63° β: 77.77° γ: 61.25°
R-values:
R R work R free
0.216 0.213 0.267
Expression system: Escherichia coli

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