› 3g5b

X-ray diffraction
2Å resolution

The structure of UNC5b cytoplasmic domain

Released:
DOI: 10.2210/pdb3g5b/pdb
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PDB entry 3g5b coloured by chain, front view.
PDB entry 3g5b coloured by chain, side view.
PDB entry 3g5b coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.
Wang R, Wei Z, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M
Mol Cell 33 692-703 (2009)
PMID: 19328064

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Netrin receptor UNC5B Chain: A
Molecule details ›
Chain: A
Length: 405 amino acids
Theoretical weight: 44.59 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O08722 (Residues: 541-945; Coverage: 44%)
Gene names: Unc5b, Unc5h2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 50.243Å b: 62.71Å c: 118.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.25
Expression system: Escherichia coli

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Citations

19 review citations

Axon guidance molecules in vascular patterning.
Adams et al. (2010)
18 more

9 mentions without citation

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.
Mitchell et al. (2019)
8 more

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