› 3hmc

X-ray diffraction
1.44Å resolution

Endolysin from Bacillus anthracis

Released:
DOI: 10.2210/pdb3hmc/pdb
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PDB entry 3hmc coloured by chain, front view.
PDB entry 3hmc coloured by chain, side view.
PDB entry 3hmc coloured by chain, top view.
Source organism: Bacillus anthracis
Primary publication:
Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins.
Low LY, Yang C, Perego M, Osterman A, Liddington R
J Biol Chem 286 34391-403 (2011)
PMID: 21816821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105712 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetylmuramoyl-l-alanine amidase C-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.64 KDa
Source organism: Bacillus anthracis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A6L7HQ02 (Residues: 1-189; Coverage: 71%)
Gene name: GBAA_0485
Sequence domains: Glycosyl hydrolases family 25
Structure domains: Glycosidases

Ligands and Environments

1 bound ligand:
Ligand MES 1 x MES
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 48.682Å b: 56.454Å c: 67.361Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.228
Expression system: Escherichia coli

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Citations

16 review citations

Bacteriophage endolysins as novel antimicrobials.
Schmelcher et al. (2012)
15 more

3 mentions without citation

Role of net charge on catalytic domain and influence of cell wall binding domain on bactericidal activity, specificity, and host range of phage lysins.
Low et al. (2011)
2 more

PDB-REDO

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