3k72

X-ray diffraction
3.7Å resolution

Structure of integrin alphaX beta2

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
PDBe Complex ID:
PDB-CPX-138498 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Integrin alpha-X Chains: A, C
Molecule details ›
Chains: A, C
Length: 1095 amino acids
Theoretical weight: 120.71 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P20702 (Residues: 20-1103; Coverage: 95%)
Gene names: CD11C, ITGAX
Sequence domains:
Structure domains:
Integrin beta-2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 687 amino acids
Theoretical weight: 75.94 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05107 (Residues: 23-699; Coverage: 91%)
Gene names: CD18, ITGB2, MFI7
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, MAN
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I212121
Unit cell:
a: 160.962Å b: 165.549Å c: 536.178Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.315 0.315 0.335
Expression system: Cricetulus griseus