3l0e

X-ray diffraction
2.3Å resolution

X-ray crystal structure of a Potent Liver X Receptor Modulator

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-157160 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Oxysterols receptor LXR-beta Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 212-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4122
Unit cell:
a: 114.855Å b: 114.855Å c: 56.407Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.237
Expression systems:
  • Escherichia coli
  • Not provided